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Bis-Tris is a zwitterionic buffering agent used in biochemistry and molecular biology.  

It is a bis(2-hydroxyethyl)amine and Tris family buffer that is useful for a pH range of 5.8 – 7.2.  

Bis Tris is a common component of many buffer systems for various types of electrophoresis.  

Bis-Tris may form a complex with some common metals, such as Cu(II) and Pb(II), and formation constants should be taken into account when using this buffer in a solution containing metal ions.  

Bis-Tris can be used as a substitute for the highly toxic buffer cacodylate.

Applications

Purification of Biological Molecules (Downstream Processing)

Raw Materials for API / Drug Substance Formulation

Cell Culture Buffer

Fractionation of Hemoglobin

Gel Electrophoresis

Diagnostics Reagents

Research and Development Buffer (R&D)

Analytical Chromatography

Non-Sterile Excipient