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IBMX is a methylated xanthine derivative.

IBMX is a phosphodiesterase inhibitor.

Applications

Competitive non-selective phosphodiesterase inhibitor which raises intracellular cAMP, activates PKA, inhibits TNFα and leukotriene synthesis, and reduces inflammation and innate immunity nonselective adenosine receptor antagonist.

As a phosphodiesterase inhibitor, IBMX has IC50 = 2–50 μM and does not inhibit PDE8 or PDE9.

IBMX to be used in the cAMP Gs and cAMP Gi kits. IBMX guarantees cAMP accumulation in the cytoplasm.