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D-Biotin is water soluble vitamin, which belongs to the B-complex group of vitamins. It generally serves as a covalently-bound coenzyme for several carboxylases. It is an essential micronutrient required for normal cell functions and can be obtained both dietary sources as well as gut microbiota.

Biotin is classified as a heterocyclic compound, with a sulfur-containing ring fused ureido and tetrahydrothiophene group. A C5-carboxylic acid side chain is appended to one of the rings. The ureido ring, containing the −N−CO−N− group, serves as the carbon dioxide carrier in carboxylation reactions.[6] Biotin is a coenzyme for five carboxylase enzymes, which are involved in the catabolism of amino acids and fatty acids, synthesis of fatty acids, and gluconeogenesis. Biotinylation of histone proteins in nuclear chromatin plays a role in chromatin stability and gene expression.

Applications

D-Biotin used throughout the biotechnology industry to isolate proteins and non-protein compounds for biochemical assays.

D-Biotin is a plant tissue culture vitamin and enzyme cofactor that enhances cGMP formation.

D-Biotin may be used as an analytical reference standard for the quantification of the analyte in food samples using high-performance liquid chromatography (HPLC)/avidin-binding assay.

D-Biotin improves the quality of keratin structures and hence has a positive effect on fine and brittle hair and nails. Although a key reputation for biotin is in hair-loss products, a combination of biotin and STAY-C® 50(patent granted) also demonstrated significant synergies in skin care applications, where it reduced age spots and evened the skin tone.

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For Research Use Only. Not for use in diagnostic procedures.